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Product Name
Human KLHL21 Recombinant protein (His tag)
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Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. {PubMed:14528312, PubMed:19995937}.
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Protein name
Kelch-like protein 21
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Protein short names
KIAA0469
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Uniprot ID
Q9UJP4
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Gene Name
KLHL21; KIAA0469
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human KLHL21 (NP_055666.2) 240-597 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human KLHL21 SDS-PAGE
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