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Product Name
Human KIR2DL4 / CD158D recombinant protein
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Description
KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
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Protein short names
KIR103; NK CELL RECEPTOR; KIR-103AS; KILLER IG RECEPTOR; XXBAC-BCX195L8.3; NATURAL KILLER CELL INHIBITORY RECEPTOR; MHC CLASS I NK CELL RECEPTOR KIR103AS; KILLER CELL INHIBITORY RECEPTOR 103AS; KIR103AS; CD158D; CD158 ANTIGEN-LIKE FAMILY MEMBER D; KIR2DL4; LONG CYTOPLASMIC TAIL; G9P; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR; 4; TWO DOMAINS; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL4
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with six amino acids (LEVLFQ) at the C-terminus was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human KIR2DL4 consists of 228 amino acids and predicts a molecular mass of 25.1 KDa. It migrates as an approximately 33-37 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human KIR2DL4 / CD158D Protein SDS-PAGE
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