Human KIR2DL3/CD158B2/KIRCL23/NKAT2 (Fc tag) recombinant protein

Human KIR2DL3/CD158B2/KIRCL23/NKAT2 (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3(KIR2DL3)

CD158B2; KIRCL23; NKAT2

P43628

Human Cells

A DNA sequence encoding the Human KIR2DL3/CD158B2/KIRCL23/NKAT2 His22-His245 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.