-
Product Name
Human KEAP1 recombinant protein
- Documents
-
Description
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:17046835}.
-
Protein name
Kelch-like ECH-associated protein 1
-
Protein short names
INRF2; KIAA0132; KLHL19
-
Uniprot ID
Q14145
-
Gene Name
KEAP1; INRF2; KIAA0132; KLHL19
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human KEAP1 (Q14145) (Gln2-Cys624) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The secreted recombinant human KEAP1 consists of 625 amino acids and predicts a molecular mass of 69.7 KDa. The apparent molecular mass of the protein is approximately 64 KDa in SDS-PAGE under reducing conditions due to glycosylation.
-
Purity
> 90 % as determined by SDS-PAGE
-
Validations
Human KEAP1 / INRF2 Protein SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"