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Product Name
Human KDM2A Recombinant protein (His tag)
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Description
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. {PubMed:16362057, PubMed:19001877}.
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Protein name
Lysine-specific demethylase 2A
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Protein short names
CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
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Uniprot ID
I3VM53
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Gene Name
KDM2A; CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human KDM2A (NP_036440.1) 374-558 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human KDM2A SDS-PAGE
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