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Product Name
Human ITSN1 Recombinant protein (GST tag)
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Description
Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. {, PubMed:11744688, PubMed:22648170}.
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Protein name
Intersectin-1
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Protein short names
ITSN; SH3D1A
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Uniprot ID
Q15811
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Gene Name
ITSN1; ITSN; SH3D1A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human ITSN1 (NP_003015.2) 610-926 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human ITSN1 SDS-PAGE
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