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Product Name
Human ILT6 / LILRA3 (His Tag) recombinant protein
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Description
ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.
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Protein name
Leukocyte immunoglobulin-like receptor subfamily A member 3
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Protein short names
HM43; XXBAC-BCX403H19.1; ILT6 / LILRA3; E3; MONOCYTE INHIBITORY RECEPTOR HM43/HM31; CD85 ANTIGEN-LIKE FAMILY MEMBER E; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 3; LIR4; IMMUNOGLOBULIN-LIKE TRANSCRIPT 6; LEUCOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR; CD85E; LIR-4; HM31; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR A3; ILT-6; LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR 4
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Uniprot ID
Q8N6C8
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Gene Name
LILRA3; ILT6; LIR4
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human LILRA3 consists of 427 amino acids and predicts a molecular mass of 46.5 KDa. It migrates as an approximately 57-66 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human ILT6 / LILRA3 Protein (His Tag) SDS-PAGE
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