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Product Name
Human IL36RN/FIL1D/IL1F5 recombinant protein
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Description
Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
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Protein name
interleukin 36 receptor antagonist(IL36RN)
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Protein short names
FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; UNQ1896; PRO4342
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Uniprot ID
Q9UBH0
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human IL36RN/FIL1D/IL1F5 Met1-Asp155 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human IL36RN/FIL1D/IL1F5 recombinant protein
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