Human CXCL10 / Crg-2 recombinant protein

Human CXCL10 / Crg-2 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.

Interleukin-36 receptor antagonist protein

C7; IP-10; INTERFERON-GAMMA INDUCED PROTEIN CRG-2; INTERFERON-INDUCIBLE CYTOKINE IP-10; MEMBER 10; SMALL INDUCIBLE CYTOKINE SUBFAMILY B (CYS-X-CYS); SCYB10; INTERFERON ACTIVATED GENE 10; IP10; GAMMA-IP10; 10 KDA INTERFERON GAMMA-INDUCED PROTEIN; MOB-1; IFI10; GAMMA IP10; GIP-10; C-X-C MOTIF CHEMOKINE 10; SMALL-INDUCIBLE CYTOKINE B10; INP10; SMALL INDUCIBLE CYTOKINE B SUBFAMILY (CYS-X-CYS); PROTEIN 10 FROM INTERFERON (GAMMA)-INDUCED CELL LINE; CRG-2

Q9UBH0

IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; UNQ1896/PRO4342

E. coli

A DNA sequence encoding the mature form of human CXCL10 (Q9UBH0) (Val22-Pro98) was expressed, with a N-terminal Met.

Human

The recombinant human CXCL10 consists of 78 amino acids and predicts a molecular mass of 8.8 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE