Human IL18BP / IL18BPa (His & Fc Tag) recombinant protein

Human IL18BP / IL18BPa (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Interleukin 18 binding protein, isoform CRA_d

MC54L; IGIFBP; IL18BPA; IL18BP; IL-18BP

O95998

IL18BP; hCG_23241

Human Cells

A DNA sequence encoding the N-terminal domain (Met 1-Gly 192) of human IL 18BPa (NP_001034748.1) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Human

The recombinant human IL18BPa/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 411 amino acids and has a predicted molecular mass of 44.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL18BPa/Fc monomer is approximately 70-75 kDa due to glycosylation.

> 95 % as determined by SDS-PAGE

Measured by its ability to bind Cynomolgus IL18 in functional ELISA.