Human IFNGR1/CD119 (His Tag) recombinant protein

Cat.#: 503455

Size:

Special Price 353.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human IFNGR1/CD119 (His Tag) recombinant protein
  • Documents
  • Description
    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.
  • Protein name
    Interferon gamma receptor 1
  • Protein short names
    IFGR; IMD27A; FLJ45734; RP3-503F13.3; IFNGR; IMD27B; IFN-GAMMAR; NKTAR; CD119; IFNGR1
  • Uniprot ID
    P15260
  • Gene Name
    IFNGR1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Gly 245) of human IFN-?R1 pre-protein (NP_000407.1) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IFN-?R1 consists of 239 amino acids after removal of the signal peptide and predicts a molecular mass of 27.3 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhIFN-?R1 is approximately 40-35 kDa due to the glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit rhIFN­γ mediated protection of WISH cells infected with vesicular stomatitis virus(VSV).
    The ED50 for this effect is typically 2-8 μg/mL.
  • Validations

    Human IFNGR1 / CD119 Protein (His Tag) SDS-PAGE

    Human IFNGR1 / CD119 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"