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Product Name
Human HOPX Recombinant protein (GST tag)
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Description
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
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Protein name
Homeodomain-only protein
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Protein short names
HOD; HOP; LAGY; NECC1; OB1
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Uniprot ID
Q9BPY8
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Gene Name
HOPX; HOD; HOP; LAGY; NECC1; OB1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human HOPX (XP_054207067.1) 39-111 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human HOPX SDS-PAGE
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