Human HINT1 Recombinant protein (GST tag)

Human HINT1 Recombinant protein (GST tag)

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Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. {PubMed:15703176, PubMed:16014379, PubMed:16835243, PubMed:19112177, PubMed:22329685, PubMed:22647378, PubMed:9323207}.

Histidine triad nucleotide-binding protein 1

HINT; PKCI1; PRKCNH1

A0A384NPU2

HINT1; HINT; PKCI1; PRKCNH1

E. coli

A DNA sequence encoding the human HINT1 (NP_005331.1) 1-126 aa was fused with the N-terminal GST tag

Human

Not tested.