Human HEPACAM (His tag) recombinant protein

Human HEPACAM (His tag) recombinant protein

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Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416). The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.

hepatic and glial cell adhesion molecule(HEPACAM)

Q14CZ8

Human Cells

A DNA sequence encoding the Human HEPACAM Val34-Ser240 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.