Human HDAC7 Recombinant protein (His tag)

Human HDAC7 Recombinant protein (His tag)

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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). {UniProtKB:Q8C2B3, PubMed:12239305, PubMed:17360565}.

Histone deacetylase 7

HDAC7A

Q8WUI4

HDAC7; HDAC7A

E. coli

A DNA sequence encoding the human HDAC7 (XP_054228220.1) 952-1035 aa was fused with the polyhistidine tag

Human

Not tested.