Human HACE1 Recombinant protein (His tag)

Human HACE1 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. {PubMed:15254018, PubMed:21988917, PubMed:22036506}.

E3 ubiquitin-protein ligase HACE1

KIAA1320

Q8IYU2

HACE1; KIAA1320

E. coli

A DNA sequence encoding the human HACE1 (NP_065822.2) 564-909 aa was fused with the polyhistidine tag

Human

Not tested.