Human GRB10 Recombinant protein (His tag)

Human GRB10 Recombinant protein (His tag)

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Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {PubMed:12493740, PubMed:15060076, PubMed:16434550, PubMed:17376403}.

Growth factor receptor-bound protein 10

GRBIR; KIAA0207

Q13322

GRB10; GRBIR; KIAA0207

E. coli

A DNA sequence encoding the human GRB10 (XP_054213926.1) 382-710 aa was fused with the polyhistidine tag

Human

Not tested.