Human GPNMB/Osteoactivin (Fc Tag) recombinant protein

Human GPNMB/Osteoactivin (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.

Transmembrane glycoprotein NMB

GPNMB; DC-HIL; UNQ1725/PRO9925; NMB; DCHIL; HGFIN; IPD; OSTEOACTIVIN

Q14956

GPNMB; HGFIN; NMB; UNQ1725/PRO9925

Human Cells

A DNA sequence encoding the human GPNMB (Q14956-2) (Met1-Pro474) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human GPNMB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 694 amino acids and has a predicted molecular mass of 77.8 kDa. The apparent molecular mass of the protein is approximately 114 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE