Human GNAI1 Recombinant protein (GST tag)

Human GNAI1 Recombinant protein (GST tag)

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Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). {UniProtKB:P10824, PubMed:17635935, PubMed:18434541, PubMed:8774883}.

Guanine nucleotide-binding protein G(i subunit alpha-1

P63096

GNAI1

E. coli

A DNA sequence encoding the human GNAI1 (NP_002060.4) 1-354 aa was fused with the N-terminal GST tag

Human

Not tested.