Human GM2A (His tag) recombinant protein

Human GM2A (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB). HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

GM2 ganglioside activator(GM2A)

P17900

Human Cells

A DNA sequence encoding the Human GM2A Ser32-Ile193 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.