Human GAMT (His tag) recombinant protein

Human GAMT (His tag) recombinant protein

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GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

guanidinoacetate N-methyltransferase(GAMT)

Q14353

E.coli

A DNA sequence encoding the Human GAMT Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.