Human FZD2 Recombinant protein (His tag)

Human FZD2 Recombinant protein (His tag)

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Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Frizzled-2

Q86UZ8

FZD2

E. coli

A DNA sequence encoding the human FZD2 (NP_001457.1) 138-217 aa was fused with the polyhistidine tag

Human

Not tested.