Human FOXA3 Recombinant protein (His tag)

Human FOXA3 Recombinant protein (His tag)

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Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {, PubMed:12695546}.

Hepatocyte nuclear factor 3-gamma

HNF3G; TCF3G

P55318

FOXA3; HNF3G; TCF3G

E. coli

A DNA sequence encoding the human FOXA3 (NP_004488.2) 1-170 aa was fused with the polyhistidine tag

Human

Not tested.