Human FGF9 (Fc Tag) recombinant protein
Fibroblast growth factor 9 (FGF9) also known as Glia-activating factor or Heparin-binding growth factor 9, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. FGF9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Fibroblast growth factor 9
Protein short names
MGC119915; HBFG-9; FGF-9; FGF9; MGC119914; SYNS3; GAF; EKS; HBGF-9
A DNA sequence encoding the mature form of human fibroblast growth factor 9 (NP_002001.1) (Leu 4-Ser 208) was expressed with the fused Fc region of human IgG1 at the N-terminus.
The recombinant human Fc/FGF9 is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a predicted molecular mass of 54 and 37 kDa as estimated in SDS-PAGE under reducing conditions duo to glycosylation.
(81.9 + 13.9) %, as determined by SDS-PAGE
Measured in a cell proliferation assay using Balb/c3T3 mouse embryonic fibroblasts (Rubin, J.S. et al. 1991. Proc. Natl. Acad. Sci. USA 88: 415.). The ED50 for this effect is typically 1-3 ng/mL.
Human FGF9 Protein (Fc Tag) SDS-PAGE
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