Human FCRL1/FCRH1 (His Tag) recombinant protein

Human FCRL1/FCRH1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I  membrane protein which contains three Ig-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.

Cystatin-S

A230020G22RIK; BXMH1B; BXMAS1; FCRH1; IRTA5; FCRL1; BXMH1; CD307A; FCRH1S; DKFZP667O1421; FCRH1L; IFGP1

P01036

CST4

Human Cells

A DNA sequence encoding the human FCRL1 (NP_001890.1) extracellular domain (Met 1-Asn 303) was fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human FCRL1 consists of 298 amino acids and has a calculated molecular mass of 32.6 kDa. It migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions due to glycosylation.

> 98 % as determined by SDS-PAGE