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Product Name
Human FANCI Recombinant protein (GST tag)
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Description
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. {PubMed:17412408, PubMed:17452773, PubMed:17460694, PubMed:19111657}.
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Protein name
Fanconi anemia group I protein
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Protein short names
KIAA1794
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Uniprot ID
Q9NVI1
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Gene Name
FANCI; KIAA1794
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human FANCI (NP_001363840.1) 180-252 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human FANCI SDS-PAGE
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