Human F13A1/F13A (His tag) recombinant protein

Human F13A1/F13A (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

coagulation factor XIII A chain(F13A1)

F13A

P00488

Human Cells

A DNA sequence encoding the Human F13A1/F13A Gly39-Met732 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.