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Product Name
Human ERO1A/ERO1L/UNQ434/PRO865 (His tag) recombinant protein
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Description
ERO1-Like Protein α (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1L acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It associates with ERP44, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. ERO1L may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell. ERO1L responses to temperature stimulus, protein thiol-disulfide exchange, protein folding with or without chaperone cofactor and transport.
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Protein name
endoplasmic reticulum oxidoreductase 1 alpha(ERO1A)
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Protein short names
ERO1L; UNQ434; PRO865
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Uniprot ID
Q96HE7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human ERO1A/ERO1L/UNQ434/PRO865 Glu24-His468 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human ERO1A/ERO1L/UNQ434/PRO865 (His tag) recombinant protein
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