Human EPRS Recombinant protein (His tag)

Human EPRS Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {PubMed:15479637, PubMed:1756734, PubMed:23071094}.

Bifunctional glutamate/proline--tRNA ligase

GLNS; PARS; QARS; QPRS

P07814

EPRS; GLNS; PARS; QARS; QPRS; PIG32

E. coli

A DNA sequence encoding the human EPRS (NP_004437.2) 1163-1512 aa was fused with the polyhistidine tag

Human

Not tested.