Human Epcr/PROCR (His Tag) recombinant protein

Human Epcr/PROCR (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 

Endothelial protein C receptor

CD201; MGC23024; RP23-388H13.2; BA42O4.2; AI325044; CCCA; EPCR; CCD41

Q9UNN8

PROCR; EPCR

Human Cells

A DNA sequence encoding the extracellular domain of human PROCR (Q9UNN8) (Met 1-Thr 209), was fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human PROCR consists of 203 amino acids and has a predicted molecular mass of 23.4 kDa. The apparent molecular mass of rhPROCR is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 97 % as determined by SDS-PAGE