Anti-PROCR antibody

Cat.#: 141695

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Product Information

  • Product Name
    Anti-PROCR antibody
  • Documents
  • Description
    Rabbit Monoclonal to Mouse PROCR
  • Tested applications
    FCM
  • Species reactivity
    Mouse Epcr/PROCR
  • Alternative names
    CCCA antibody; EPCR antibody; CCD41 antibody; Ccca antibody; Epcr antibody; Ccd41 antibody; AI325044 antibody; AI325044 antibody; bA42O4.2 antibody; CCCA antibody; Ccca antibody; Ccd41 antibody; CCD41 antibody; CD201 antibody; EPCR antibody; Epcr antibody; MGC23024 antibody; RP23-388H13.2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Epcr/PROCR and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    Mouse Epcr/PROCR Flow Cytometry (FC) 15368

    Mouse Epcr/PROCR Flow Cytometry (FC) 15368

  • Background
    Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"