Human EPB49 Recombinant protein (His tag)

Human EPB49 Recombinant protein (His tag)

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• Material Safety Data Sheets (MSDS)

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {PubMed:10565303, PubMed:11856323, PubMed:18347014, PubMed:19241372, PubMed:22927433, PubMed:23355471}.

Dematin

DMT; EPB49

Q08495

DMTN; DMT; EPB49

E. coli

A DNA sequence encoding the human DMTN (NP_001310310.1) 1-405 aa was fused with the polyhistidine tag

Human

Not tested.