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Product Name
Human EPAS1 Recombinant protein (GST tag)
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Description
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
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Protein name
Endothelial PAS domain-containing protein 1
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Protein short names
BHLHE73; HIF2A; MOP2; PASD2
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Uniprot ID
Q53SM6
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Gene Name
EPAS1; BHLHE73; HIF2A; MOP2; PASD2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human EPAS1 (XP_011531000.1) 22-363 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human EPAS1 SDS-PAGE
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