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Product Name
Human Endothelial Cell Adhesion Molecule (His Tag) recombinant protein
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Description
Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.
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Protein name
Endothelial cell-selective adhesion molecule
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Protein short names
2310008D05RIK; ESAM1; ESAM; W117M
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Uniprot ID
Q96AP7
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Gene Name
ESAM; UNQ220/PRO246
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Ala 248) of human ESAM (NP_620411.2) precursor was expressed,with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ESAM consists of 230 amino acids and predicts a molecular mass of 25.4 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rh ESAM is approximately 35-40 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human ESAM / Endothelial Cell Adhesion Molecule Protein (His Tag) SDS-PAGE
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