Human EFCAB4B Recombinant protein (His tag)

Human EFCAB4B Recombinant protein (His tag)

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Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {PubMed:20418871}.

EF-hand calcium-binding domain-containing protein 4B

EFCAB4B

Q9BSW2

CRACR2A; EFCAB4B

E. coli

A DNA sequence encoding the human CRACR2A (NP_116069.1) 1-395 aa was fused with the polyhistidine tag

Human

Not tested.