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Product Name
Human DPYS / Dihydropyrimidinase recombinant protein
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Description
DPYS, also known as dihydropyrimidinase, belongs to the DHOase family, hydantoinase/dihydropyrimidinase subfamily. DPYS catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. It can catalyzes the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. DPYS is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
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Protein name
Dihydropyrimidinase
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Protein short names
1200017I10RIK; 1300004I01RIK; HYDANTOINASE; DIHYDROPYRIMIDINASE; DHP; DHPASE; DIHYDROPYRIMIDINE AMIDOHYDROLASE; DPYS
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Uniprot ID
Q14117
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Gene Name
DPYS
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human DPYS (NP_001376.1) (Met1-Pro519) was fused with two additional amino acids (Gly&Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human DPYS consists of 521 amino acids and has a calculated molecular mass of 56.8 kDa. The recombinant protein migrates as an approximately 54 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human DPYS / Dihydropyrimidinase Protein SDS-PAGE
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