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Product Name
Human DNAJC3 Recombinant protein (His tag)
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Description
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {UniProtKB:Q27968, UniProtKB:Q91YW3, PubMed:12601012, PubMed:8576172, PubMed:9447982, PubMed:9920933}.
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Protein name
DnaJ homolog subfamily C member 3
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Protein short names
P58IPK; PRKRI
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Uniprot ID
Q13217
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Gene Name
DNAJC3; P58IPK; PRKRI
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DNAJC3 (NP_006251.1) 32-380 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human DNAJC3 SDS-PAGE
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