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Product Name
Human DNAJA1 Recombinant protein (GST tag)
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Description
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {PubMed:10816573, PubMed:14752510, PubMed:24318877, PubMed:24512202, PubMed:9192730}.
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Protein name
DnaJ homolog subfamily A member 1
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Protein short names
DNAJ2; HDJ2; HSJ2; HSPF4
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Uniprot ID
P31689
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Gene Name
DNAJA1; DNAJ2; HDJ2; HSJ2; HSPF4
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DNAJA1 (NP_001530.1) 1-397 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human DNAJA1 SDS-PAGE
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