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Product Name
Human DLC1 Recombinant protein (His tag)
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Description
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {PubMed:18786931, PubMed:19170769, PubMed:19710422}.
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Protein name
Rho GTPase-activating protein 7
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Protein short names
ARHGAP7; KIAA1723; STARD12
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Uniprot ID
A0A2X0SYX6
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Gene Name
DLC1; ARHGAP7; KIAA1723; STARD12
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DLC1 (NP_872584.2) 1179-1528 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human DLC1 SDS-PAGE
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