Human DEAF1 Recombinant protein (His tag)

Human DEAF1 Recombinant protein (His tag)

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Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. {PubMed:10521432, PubMed:11427895, PubMed:11705868, PubMed:18826651, PubMed:19668219, PubMed:24726472}.

Deformed epidermal autoregulatory factor 1 homolog

SPN; ZMYND5

O75398

DEAF1; SPN; ZMYND5

E. coli

A DNA sequence encoding the human DEAF1 (NP_066288.2) 1-316 aa was fused with the polyhistidine tag

Human

Not tested.