Human DDX5 Recombinant protein (GST tag)

Human DDX5 Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {PubMed:10409727, PubMed:11250900, PubMed:12527917, PubMed:15298701, PubMed:15660129, PubMed:17011493, PubMed:17960593, PubMed:18829551, PubMed:19718048, PubMed:21343338}.

Probable ATP-dependent RNA helicase DDX5

G17P1; HELR; HLR1

J3KTA4

DDX5; G17P1; HELR; HLR1

E. coli

A DNA sequence encoding the human DDX5 (NP_004387.1) 434-614 aa was fused with the N-terminal GST tag

Human

Not tested.