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Product Name
Human Cyclin D3 Recombinant protein (His tag)
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Description
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {PubMed:15358120}.
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Protein name
G1/S-specific cyclin-D3
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Uniprot ID
P30281
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Gene Name
CCND3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human CCND3 (NP_001751.1) 1-292 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human Cyclin D3 SDS-PAGE
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