Human CXCL11/ITAC/SCYB11/SCYB9B recombinant protein

Human CXCL11/ITAC/SCYB11/SCYB9B recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Chemokine Ligand 11 (CXCL11) is a non-ELR (lacking the Glu-Leu-Arg tripeptide motif) CXC chemokine. CXCL11 is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family. CXCL11 cDNA encodes a 94 amino acid residue precursor protein with a 21 amino acid residue putative signal sequence, which is cleaved to form the mature 73 amino acid residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with IP-10 and MIG (two other known human non-ELR CXC chemokines), respectively. Mouse CXCL11 exhibits 68% sequence homology with humanCXCL11. In humans, CXCL11, IP-10 and MIG all map to the same locus on chromosome 4.

C-X-C motif chemokine ligand 11(CXCL11)

ITAC; SCYB11; SCYB9B

O14625

E. coli

A DNA sequence encoding the Human CXCL11/ITAC/SCYB11/SCYB9B Phe22-Phe94 is expressed.

Human

>95% as determined by SDS-PAGE.