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Product Name
Human CRCP Recombinant protein (His tag)
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Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
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Protein name
DNA-directed RNA polymerase III subunit RPC9
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Uniprot ID
O75575
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Gene Name
CRCP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human CRCP (NP_001135886.1) 28-141 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human CRCP(Full length) SDS-PAGE
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