-
Product Name
Human CNOT2 Recombinant protein (His tag)
- Documents
-
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {PubMed:14707134, PubMed:16712523, PubMed:21299754, PubMed:22367759}.
-
Protein name
CCR4-NOT transcription complex subunit 2
-
Protein short names
CDC36; NOT2
-
Uniprot ID
Q9NZN8
-
Gene Name
CNOT2; CDC36; NOT2; HSPC131; MSTP046
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the human CNOT2 (NP_001186232.1) 336-540 aa was fused with the polyhistidine tag
-
Protein Species
Human
-
Activity
Not tested.
-
Validations
Recombinant human CNOT2 SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"