Human CHN1 / chimerin 1 (His & GST Tag) recombinant protein

Human CHN1 / chimerin 1 (His & GST Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CHN1, also known as chimerin 1, is a TPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. CHN1 is involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. The CHN1 gene provides instructions for making two very similar proteins called ?1-chimaerin and ?2-chimaerin. These proteins play an important role in the early development of the nervous system. In particular, they help regulate complex chemical signaling pathways during the formation and development of nerve cells (neurons). These proteins help guide the growth of axons and dendrites, which are specialized extensions of neurons that transmit and receive nerve impulses throughout the nervous system.

N-chimaerin

ALPHA2 CHIMAERIN; 2900046J01RIK; ARHGAP2; N-CHIMERIN; A2-CHIMAERIN; 1700112L09RIK; CHIMERIN 1; NC; A-CHIMAERIN; CHIMAERIN; RHOGAP2; CHN1; RP23-271L22.3; DURS2; CHIMERIN (CHIMAERIN) 1; CHN; 0710001E19RIK; ALPHA3-CHIMERIN; N-CHIMAERIN; 0610007I19RIK; ALPHA-CHIMERIN; RHO GTPASE-ACTIVATING PROTEIN 2; CHIMAERIN 1; ALPHA1 CHIMAERIN; AI413815

P15882

CHN1; ARHGAP2; CHN

Baculovirus-Insect Cells

A DNA sequence encoding the human CHN1 (NP_001813.1) (Ala2-Phe459) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Human

The recombinant human CHN1/GST chimera consists of 695 amino acids and has a calculated molecular mass of 80.9 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE