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Product Name
Human CENPA Recombinant protein (GST tag)
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Description
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). {PubMed:20739937, PubMed:21478274}.
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Protein name
Histone H3-like centromeric protein A
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Uniprot ID
P49450
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Gene Name
CENPA
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
1-59 aa encoded by NM_001809 was inserted into PGEX-4T vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human CENPA SDS-PAGE
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