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  • Human CD99/MIC2/MIC2X/MIC2Y (Fc tag) recombinant protein

Human CD99/MIC2/MIC2X/MIC2Y (Fc tag) recombinant protein

Cat.#: 518109

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Product Information

  • Product Name
    Human CD99/MIC2/MIC2X/MIC2Y (Fc tag) recombinant protein
  • Documents
  • Description
    CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48% aa sequence identity to mouse CD99.
  • Protein name
    CD99 molecule(CD99)
  • Protein short names
    MIC2; MIC2X; MIC2Y
  • Uniprot ID
    P14209
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human CD99/MIC2/MIC2X/MIC2Y Asp23-Asp122 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human CD99/MIC2/MIC2X/MIC2Y (Fc tag) recombinant protein

    Human CD99/MIC2/MIC2X/MIC2Y (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"