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Product Name
Human CCDC99 Recombinant protein (GST tag)
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Description
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {HAMAP-Rule:MF_03041, PubMed:17576797, PubMed:19468067}.
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Protein name
Protein Spindly
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Protein short names
CCDC99
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Uniprot ID
Q96EA4
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Gene Name
SPDL1; CCDC99
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SPDL1 (XP_054208849.1) 259-605 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human CCDC99 SDS-PAGE
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