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Product Name
Human CCDC109A Recombinant protein (GST tag)
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Description
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:26341627). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). {PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:24332854, PubMed:24560927, PubMed:26341627}.
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Protein name
Calcium uniporter protein, mitochondrial
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Protein short names
C10orf42; CCDC109A
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Uniprot ID
Q8NE86
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Gene Name
MCU; C10orf42; CCDC109A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MCU (NP_612366.1) 155-233 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human CCDC109A SDS-PAGE
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